Displaying 1 - 30 of 98 in total
A Saudi Startup Makes History in Gene Therapy
For this exciting conversation, I am joined by NanoPalm CEO and co-founder Dr. Ali Alhasan and by Charles River Executive Director Ramin Baghirzade, who joins us to ta...
From Tumor to Treatment: How PDX Models are Powering Cancer Breakthroughs
What if a mouse could help shape the future of cancer treatment? In this episode of Sounds of Science, host Mary Parker speaks with Julia Schüler, DVM, PhD, Research D...
Microbiologists in Manufacturing
Join me, Charles River’s Miriam Guest, and independent consultant Vanessa Figueroa as we tackle the role of a microbiologist in drug manufacturing. Who is keeping pati...
Behind the Breakthroughs: Rethinking Animal Research with the 3Rs
What happens when cutting-edge science meets compassion? In this episode of Sounds of Science, host Mary Parker sits down with two pioneers reshaping the future of res...
What Makes a Virus Contagious?
Join Charles River experts Sandy Kimber, Charlotte Cumper, and Claire Richards from our Portishead site for a discussion on what makes some viruses more contagious tha...
The Journey of Susannah’s Personalized ASO
When Luke Rosen's daughter was diagnosed with KIF1A—a rare, progressive neurological disorder—he didn't wait for answers. He and his wife built a community, launched a...
Evolving Animal Welfare: Science, Ethics, and Innovation
Are we on the brink of a major shift in research? In this episode of Sounds of Science, Charles River experts challenge traditional approaches, exploring cutting-edge ...
Cancer Vaccines, Then and Now
Did you know that the first attempt at a cancer vaccine was all the way back in the 1800s? I am joined by Charles River experts Louise Brackenbury, Dan Rocca, and Mike...
All About Spheroids
Spheroids are three dimensional cell models that can mimic some organs, tumors, and other biological systems for drug testing. Like organoids and organs-on-a-chip, sph...
Ep. 89: Rethinking Toxicology: The Future of NAMs in Agrochemicals
The agrochemical field has long relied on animal models to evaluate the safety and efficacy of substances, but there’s a growing demand to adopt new alternative method...
Ep. 88: The Epidemiology of Cancer
How can genetic, geographic, and social considerations effect outcomes for Black women with cancer? To answer this question, I am joined this week by Dr. Lauren E. McC...
Ep. 87: Taking a Customized and Collaborative Approach to Therapeutic Development
The N=1 Collaborative is changing the way we view drug development. Their specialty is creating customized therapies tailored to individual patients, paving the way fo...
Ep. 85: The Next Generation of Drug Development
Artificial intelligence and machine learning are launching a new era in drug development. By integrating these technologies, researchers can get their life-saving ther...
Ep. 84: A Family's Fight Against Batten Disease
David and Karen Kahn were overjoyed when they welcomed twins Amelia and Makenzie in 2010. However, it wasn't long before they realized their girls were different. Sinc...
Ep. 83: NAMs: The Future of Research?
As researchers look for ways to reduce the need for animals in their studies, new alternative methods (NAMs) are an intriguing route to capture crucial safety data and...
Ep. 82: Taking PrEP to the Next Level
Dr. Jared Baeten, Senior Vice President of Clinical Development and Virology Therapeutic Area Head at Gilead Sciences, joins me to discuss the incredible advancements ...
Ep. 81: Biomedical Engineering: The Future of Research?
As researchers continue to look for new ways to test therapeutics in vitro, the field of biomedical engineering is offering new microphysiological systems that can red...
Ep. 80: Diversity in Veterinary Medicine
I am joined by Raphael (Ralph) Malbrue, Director & Attending Veterinarian, Center for Comparative Medicine, University of Virginia; and Christina (Winnie) Winnicker, E...
Ep. 79: Painting a Picture of Hope to Treat PACS2
Piotr Kosla, founder of the PACS2 Research Foundation, joins us to discuss his personal motivation to develop the first treatment for Development and Epileptic Encepha...
Ep. 78: Starting Over After Cancer
Lisa Sharp, Project Coordinator for Charles River, joins us to discuss her COVID lockdown experience. Right at the beginning of the pandemic, just weeks apart, both sh...
Ep. 77: Ophirex: Biting Back
Imagine you’re exploring the great outdoors when, out of nowhere, you feel the fangs of a snake – a poisonous snake – breaking through your skin. Medical care is nowhe...
Ep. 76: Multi-Organ Chip Systems
I am joined by Dr. Kacey Ronaldson-Bouchard from Columbia University, who is an expert on linking organs on a chip together to form models of human systems. Can these ...
Ep. 75: Porcine Kidneys for Human Transplant
Mike Curtis, president and CEO of eGenesis, and transplant surgeon Dr. Leonardo Riella join me to discuss the ongoing research into pig kidney to human transplants. Ho...
Ep. 74: One Patient's Sickle Cell Story
Felicia Samuel has worked for Charles River for years, but recently the work she contributes to has taken on a new meaning. Her daughter will be part of a clinical tri...
Ep. 73: Virtual Control Groups
What if we could replace mouse model control groups with a virtual equivalent? What would that mean for drug development in terms of cost, time, and animal model reduc...
Ep. 72: Artificial Intelligence in Cell and Gene Therapy
Alex Sargent, Director of Process Development at Charles River in our Cell and Gene Therapy department, joins me to discuss the work he and his partner put into develo...
Ep. 71: Cellular Agriculture - Lab Grown Meat of the Future
There have been many articles recently about cellular agriculture, or lab-grown meat products. But what happens when a company takes a practical approach to this scien...
Ep. 70: Benjamin Oakes and the Promise of CRISPR
This month I am joined by Benjamin Oakes, scientist, entrepreneur, and co-founder of Scribe Therapeutics. He studied at UC Berkeley, working in the Doudna Lab and Sava...
Ep. 69: Past and Future of Endotoxin Testing
Norm Wainwright and Foster Jordan have been immersed in the field of limulus amebocyte lysate (LAL) testing for decades, and have seen the progress and refinement of t...
Ep. 68: Looking Ahead in 2024
I am joined by four experts in their field to discuss what will be hot in rare diseases, drug discovery, artificial intelligence, and animal models in 2024.